Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent

SICA REP; DE NICOLA AF; GONZALEZ DENISELLE M.C; RODRIGUEZ G; GARGIULO MONACHELLI GM; PERALTA LM; BETTINI M

ARQUIVOS DE NEURO-PSIQUIATRIA

ASSOC ARQUIVOS NEURO- PSIQUIATRIA

Año: 2011 vol. 69 p. 699 - 706

0004-282X

This article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity,oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis that astrocytes may be the cells which serve as targets for the harmful action of a still unknown environmental agent, while neuronal death may be a secondary event following the initial insult to glial cells. The article also suggests that an emergent virus or a misfolded infectious protein might be potential candidates to accomplish this task.