IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Progesterone and the spinal cord: good friends in bad times
Autor/es:
LABOMBARDA F; GONZÁLEZ DENISELLE, M.C.; DE NICOLA A. F.; GONZALEZ SL
Revista:
NEUROIMMUNOMODULATION.
Editorial:
KARGER
Referencias:
Año: 2010 vol. 17 p. 146 - 149
ISSN:
1021-7401
Resumen:
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In recent years, a
growing list of publications point to the value of steroid hormones as an
interesting option for the treatment of several type of lesions and diseases of
the nervous
system. Progesterone,
well known for its role in pregnancy, has recently been shown to exert
neuroprotective and promyelinating effects in both, the peripheral and central
nervous system, including the injured spinal cord. Previous work from our
laboratory has shown that progesterone actions in experimental models of spinal
neurodegeneration or injury may involve the modulation of brain-derived
neurotrophic factor, a neurotrophin with important implications in neuronal
survival and axonal regeneration. The spinal cord is target for progesterone
since neurons and glial cells express the intracellular receptors for this
neuroactive steroid. However, the presence in the spinal cord of new membrane
receptors and the enzymes involved in progesterone metabolism to its reduced
derivatives, which modulate
the activity of
neurotransmitter receptors, suggest that progesterone actions involve
pleiotropic mechanisms. Our recent data uncovering several molecular events may
help to understand the protective and promyelinating actions of progesterone
and further support the role of this steroid as a promising therapeutic agent
for neurotrauma and/or neurodegenerative diseases.