Dynamic Response of Electrocardiographic Indices During Abrupt Heart Rate Changes: Comparison Between Young and Middle-Aged Subjets

TEPERINO M.J.; BONOMINI M.P:; CRUCES P.D.; ARINI P.D.

Lisbon

Conferencia; 8th International Conference on Bio-Inspired Systems and Signal Processing; 2015

Abnormal modifications in heterogeneity of ventricular repolarization have been shown to constitute a substrate for malignant arrhythmias. In this work, we have induced abrupt heart rate (HR) changes to 17 healthy subjects through a Tilt-test Maneuver and have analyzed the evolution of several VRD indices in two groups: young and middle-aged subjescts. Duration ones, based on ECG intervals; energy ones, developed through a Principal Components Analysis in T-wave; and the morphology one, extracted feature from an absolute T-wave. Results have shown statistically significant decreases in early repolarization duration, finding that these changes are responsible for the alterations in the total repolarization duration. Also, simultaneously it has been observed that T-wave peak-to-end has not shown statistical significance. Moreover, we have found statistically significant decreases total, early and late energy of the T-wave respectively. On the other hand, we have observed statistically significant decreases in the T-wave amplitude and a shifting of the T-wave peak position towards the QRS-complex. We have concluded that the repolarization energy of total evaluated from PCA procedure have been able to reflects VRD differences between young and middle-aged healthy subjects. Finally, this work provides the range of values for VRD in normal conditions during abrupt HR changes. Outside this range, we could suppose that it exists a cardiac risk.