Electrocardiography in Wistar Rat Experimental Model: Analysis and Characterization

PEDRO D ARINI; GUILLERMO BERTRÁN ; SANTIAGO FEDERICO CARACCIOLO

Revista argentina de bioingeniería

Sociedad Argentina de Bioingeniería

Año: 2018 vol. 22 p. 7 - 12

0329-5257

The experimental model of Wistar rat(WR) is widely used by the scientific community for the evaluation ofxenobiotics and environmental stressors. However, in spite of its great use,few publications have explicitly reported the differences between theparameters obtained from the ECG delineation and the different variablesinvolved in the settings of a Wistar rat experiment. Variables such as suppliedanesthesia, sex, age, weight, movement restriction and lead used influence theelectrocardiographic parameters analyzed, such as RR, QT, PR intervals, P andQRS durations and peak amplitudes of P, Q, R, S, and T-waves. The firstspecific objective of this work is to organize the electrocardiographicparameters that have already been published by the scientific communityaccording to their experimental setup. The second specific objective is toprovide new parameters, such as the JTend and Tpe intervals, to the state of the art of Wistar ratECG characterization. For this purpose, a database of 48 Wistar ratscategorized by sex and age, measured in lead II, was processed and delineated.