A novel method for cardiac vector velocity measurement: Evaluation in myocardial infarction.

PEDRO DAVID ARINI; PABLO DANIEL CRUCES

BIOMEDICAL SIGNAL PROCESSING AND CONTROL

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2016 vol. 28 p. 58 - 62

1746-8094

Background and objective: Pathological alterations provoked by myocardial infarction cause slow conduc-tion by increasing axial resistance on coupling between cells. This issue may cause abnormal patterns inthe dynamics of the tip of the cardiac vector. Methods: In this work, we have developed a method to compute the angular velocity during ventricularrepolarization from Frank XYZ leads, using the concept of quaternion. This parameter jointly with thelinear velocity obtained by differentiation and the spatial velocity reported by others during ventriculardepolarization, have been combined in order to design a myocardial infarction detector (so-called indexof cardiac vector velocity: ICVV) with high values of sensitivity and specificity simultaneously. Results: The predictive power of ICVV has been tested in two groups: patients with less than 7 daysafter infarction, achieving 98% of sensitivity and 97% of specificity; and patients with more than 45 daysafter infarction, achieving 92% of sensitivity without loss of specificity. The former group is importantfor early detection of myocardial infarction and begins treatment in a short period of time on emergencydepartment. The latter involves the evaluation of the cardiac vector velocity after the period of post-infarction electrical remodeling which may be useful in the follow-up of patients. Conclusions: We have concluded that this method extends the concept of cardiac vector velocity and maybe useful in the diagnosis of myocardial infarction.