IAM   02674
INSTITUTO ARGENTINO DE MATEMATICA ALBERTO CALDERON
Unidad Ejecutora - UE
artículos
Título:
The allometric model in chronic myocardial infarction
Autor/es:
MARIA P BONOMINI; PEDRO D. ARINI; GERMÁN E GONZALEZ; BRUNO BUCHHOLZ; MAX E. VALENTINUZZI
Revista:
THEORETICAL BIOLOGY AND MEDICAL MODELLING
Editorial:
BIOMED CENTRAL LTD
Referencias:
Lugar: Londres; Año: 2012 vol. 9 p. 1 - 13
ISSN:
1742-4682
Resumen:
Background: An allometric relationship between different
electrocardiogram (ECG)
parameters and infarcted ventricular mass was assessed in a myocardial
infarction
(MI) model in New Zealand rabbits. Methods: A total of fifteen animals
were used, out of which ten underwent left anterior descending coronary artery
ligation to induce infarction (735% area).
Myocardial infarction (MI) evolved and stabilized during a three
month-period, after which, rabbits were sacrificed and the injured area was
histologically confirmed. Right before sacrifice, ECGs were obtained to
correlate several of its parameters to the infarcted mass. The latter was
normalized after combining data from planimetry measurements and heart weight.
The following ECG parameters were studied: RR and PR intervals, P-wave duration
(PD),
QRS duration (QRSD)
and amplitude (QRSA), Q-wave
(QA),
R-wave (RA)
and S-wave (SA)
amplitudes, T-wave peak amplitude (TA),
the interval from the peak to the end of the T-wave (TPE), ST-segment
deviation (STA),
QT interval (QT), corrected QT and JT intervals. Corrected QT was analyzed with
different correction formulae, i.e., Bazett (QTB), Framingham (QTFRA), Fridericia (QTFRI), Hodge (QTHO) and Matsunaga (QTMA) and compared thereafter. The former variables and
infarcted ventricular mass were then fitted to the allometric equation in terms
of deviation from normality, in turn derived after ECGs in 5 healthy rabbits. Results:
Six variables (JT, QTB, QA, SA, TA and STA) presented
statistical differences
among leads. QT showed the best allometric fit (r = 0.78), followed by TA (r = 0.77), STA (r = 0.75), QTFRA (r =
0.72), TPE (r = 0.69), QTFRI (r = 0.68) and QTMA (r = 0.68). Corrected QTs (QTFRA, QTFRI and QTMA) performed worse than the uncorrected counterpart
(QT), the former scaling allometrically with similar goodness of fits. Conclusions:
QT, TA, STA and TPE could possibly
be used to assess infarction extent in an old MI event through the allometric
model as a first approach. Moreover, the
TPE also produced a good allometric scaling, leading to
the potential existence of promising allometric indexes to diagnose malignant
arrhythmias.