IAM   02674
INSTITUTO ARGENTINO DE MATEMATICA ALBERTO CALDERON
Unidad Ejecutora - UE
artículos
Título:
Epistructural tension promotes protein associations
Autor/es:
ARIEL FERNANDEZ
Revista:
PHYSICAL REVIEW LETTERS
Editorial:
AMER PHYSICAL SOC
Referencias:
Lugar: New York; Año: 2012 vol. 108 p. 188102 - 188102
ISSN:
0031-9007
Resumen:
Epistructural tension is the reversible work per unit area required to span the aqueous interface of a soluble protein structure. The parameter accounts for the free-energy cost of imperfect hydration, involving water molecules with a shortage of hydrogen bonding partnerships relative to bulk levels. The binding hot spots along protein-protein interfaces are identified with residues that contribute significantly to the epistructural tension in the free subunits. Upon association, such residues either displace or become deprived of low-coordination vicinal water molecules.