NICOTINIC MODULATION OF THE RESPONSE TO PACLITAXEL IN TRIPLE NEGATIVE BREAST CANCER CELLS

AGUSTINA SALEM; ALEJANDRO ESPAÑOL; YAMILA SANCHEZ; MARIA ELENA SALES; JAQUELIN OBREGON

Congreso; LXVI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2021

SAIC

Previous evidences pointed to the participation of nicotinic acetylcholine receptors (nAChRs) in the effect of paclitaxel (PX) as an antitumor agent in lung cancer. However, less knowledge is available regarding the actions of PX on nAChRs in nearby organs such as those of the breasts. The addition of nicotine (NIC) confirmed the presence of functional nAChRs in mammary cells which mediated an increment in cell viability measured by MTT assay. This effect was more potent in MDA-MB231 triple negative tumor cells (189±2%) than in MCF-10A non-tumor cells (145±7%; p