CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Fetal activation of PPAR: Metabolic effects in the liver and the placenta.
Autor/es:
MARTINEZ NORA; KURTZ MELISA; WHITE VER&243NICAA; JAWERBAUM ALICIA
Lugar:
Santiago
Reunión:
Congreso; International Federation of Placenta Associations Meeting: “Fetus and Placenta: a perfect harmony”; 2010
Institución organizadora:
nternational Federation of Placenta Associations- Simposio Latinoamericano de Intercambio Materno-Fetal.
Resumen:
Maternal diabetes induces alterations in lipid and nitric oxide (NO) metabolism and affects feto-placental development and growth. PPAR alpha is a nuclear receptor involved in lipid homeostasis in different tissues. Objective: To analyze whether fetal PPARá activation regulate lipid and NO metabolism in the placenta and fetal liver from diabetic rats, and its involvement the feto-placental growth. Methods: Diabetes was induced by neonatal streptozotocin administration. Fetuses from control and diabetic rats were injected through the uterine wall with the PPARá agonist leukotriene (0.1M) on days 19, 20, and 21 of gestation. On day 21 of gestation, placental and fetal liver concentrations of lipids, lipoperoxides and NO were evaluated. Results: Fetuses and placenta from diabetic rats showed increased weight (p