The enrichment of maternal environment promotes vascular remodeling at the maternal-fetal interface during early gestation in mice.

SCHANDER, JULIETA A.; RIBEIRO, MARÍA LAURA; DE LA CRUZ BORTHIRY, FL; CELLA, MAXIMILIANO; BELTRAME JS; FRANCHI, AM

Modo virtual

Congreso; 53rd SSR Annual meeting; 2020

First trimester events associated to implantation are crucial for pregnancy success. Defects in these processes have been associated to the onset of many obstetric pathologies. In particularly, failure in vascular remodeling at the maternal-fetal interface affects blood supply to the fetus and increases maternal blood pressure. Therefore, it has been correlated with preeclampsia and intrauterine growth restriction. Maternal lifestyle affects the development of pregnancy. Therapies oriented to reduce stress and physical activity have shown to improve pregnancy outcome. Furthermore, stress during gestation is associated with preeclampsia, which is linked to defective vascular remodeling at the early placenta. We have previously demonstrated that female mice exposed preconceptionally and during gestation to an enriched environment (EE) present higher reproductive efficiency in day 15 of gestation, compared to females maintained in control environment (CE) (80% vs 40%, p