Maternal diets enriched in sunflower and chia oil administrated during early postimplantation prevent morphological anomalies in the fetus, decidua and placenta of diabetic rats at day 14 of pregnancy

ROBERTI, SABRINA L.; HIGA, ROMINA; HEINECKE, FLORENCIA; JAWERBAUM, ALICIA; GOMEZ RIBOT, DALMIRO

Río de Janeiro (virtual)

Congreso; LATIN AMERICAN DOHaD 2020. One World One Health. On the Web.; 2020

Latin American DOHaD Chapter

ObjectivesThe postimplantation period is crucial for the embryo development and the correct establishment of the future placenta. The decidua plays an essential role in this process and its impaired function may lead to embryo resorption. Diabetes mellitus is a metabolic pathology that affects decidual, embryo and placental development. In the rat, the decidua from day-9-pregnant rats showed alterations in both PPAR and mTOR pathways. PPARs are involved in lipid metabolism, development and antioxidant pathways whereas mTOR is a nutritional sensor involved in cell growth, proliferation and migration. We previously found that decidual PPAR and mTOR pathways are regulated by diets enriched in sunflower oil (rich in PUFAs n-6) or chia oil (rich in PUFAs n-3) in 9-day-pregnant diabetic rats. Here, we hypothesized that maternal diets enriched with sunflower and chia oil, administrated from days 7 to 9 of pregnancy, can improve fetal, decidual and placental growth in 14-day-pregnant diabetic rats.MethodsDiabetes was induced in female rats by streptozotocin administration (50 mg/kg) two weeks before mating. Diabetic rats received a standard diet or a diet enriched either in 6% sunflower oil or 6% chia oil from days 7 to 9 of pregnancy. On day 14 of pregnancy, the fetus, decidua and placenta were explanted. The cephalic length was measured in the fetuses and the placenta and decidua were weighed. The resorption rate was registered.ResultsWe found an increase in the resorption rate in the diabetic group (120%, p