Evidence for resveratrol modulating inflammatory madiators of maternal immune activation

TICCHI JULIA; CORREA FERNANDO

Simposio; INTERNATIONAL SYMPOSIUM ON REPRODUCTIVE HEALTH; 2021

Maternal immune activation (MIA) produces structural, metabolic, and epigenetic changes in the fetus associated with increased risk for various neurodevelopmental and neurodegenerative disorders. The activation of microglia is one of the main effectors of the innate immune response in the CNS. Excessive microglial activation leads to CNS damage due to excessive production of pro-inflammatory mediators, like interleukins, MMP, PGE2, and ROS.It has been demonstrated that resveratrol has anti-inflammatory, antioxidant properties that translate into neuroprotective effects in adults.