Paternal Programming: Sex-dependent Effects In The Placenta Of Fetuses From Male Diabetic Rats

HEINECKE, FLORENCIA; CAPOBIANCO, EVANGELINA; FORNES, DAIANA; JAWERBAUM, ALICIA; WHITE, VERÓNICA

Congreso; 4th Meeting of DOHaD Latin American-Chapter; 2020

Embasamento/Background: Paternal exposure to diabetes can lead to the transmission of metabolic disorders in the offspring. Our aim was to assess sex-dependent lipid alterations in the placenta of fetuses from diabetic males.Métodos/Methods: Control and type 2 diabetic male rats (diabetes obtained by intrauterine programming in the offspring of streptozotocininduced diabetic rats, glycemia: 140-190 mg/dL) were mated with control female rats. On day 21 of gestation, the placenta of male and female fetuses was obtained for the evaluation of lipid levels (by TLC) and mRNA of genes involved in lipid metabolism (by RT-qPCR).Resultados/Results: Fetal weight was increased in both males and females of diabetic group (15%, p