Oral administration of butyrate to overweight pregnant rats prevents fetal and placental alterations

FLORENCIA HEINECKE, ROMINA HIGA, ALICIA JAWERBAUM, VERÓNICA WHITE; FLORENCIA HEINECKE, ROMINA HIGA, ALICIA JAWERBAUM, VERÓNICA WHITE

Simposio; III Simposio Colombiano de placenta e Interacción materno-fetal 2020; 2020

Maternal obesity programs anomalies in fetuses and placentas. Butyrate, a product of fiber metabolism from the intestinal microbiota, improves lipid and glucose homeostasis. Our aim was to address whether oral administation of butyrate prevents fetal and placental alterations in pregnancy from overweight rats. Female rats fed a control or fatty diet (FD, 28% of fat) were mated with control males. Butyrate (3%) or vehicle, was orally delivered daily during gestation. The rats were euthanized at 21 days of gestation, fetuses, fetal livers and placentas were obtained, and weighed. Maternal and fetal plasma was obtained by decapitation.Butyrate prevented maternal hypertriglyceridemia and macrosomia in FD fetuses (p