Behavioral Disorders Caused by Acute Carbon Monoxide Poisoning and Its Relationship with Prognostic Biomarkers

CORTEZ, A; MENEGHINI, M; MOLINA, SJ; FALETTI, A; GALARZA, R; KARADAYIAN, A

Honolulu, Hawaii

Congreso; IUTOX 15th International Congress of Toxicology; 2019

Society of Toxicology

Carbon monoxide poisoning (CO) is preventable and avoidable. Hundreds ofpeople die by acute intoxication to CO, and many of them suffer the so-calledlate neurological syndrome (LNS) with irreversible consequences. The aims ofthe present work were to assess the effects of an acute exposure to CO on thebehavior, memory, anxiety, and gait dynamics and to relate these changes tosome prognostic biomarkers. To this end, adult rats were exposed to CO atacute doses (350 ppm for 20 seconds) capable of causing deterioration of thesensorium, and different tests were performed seven days post-intoxication.Compared with control animals (C), rats exposed to CO showed changes inthe (i) footprint test expressed as cm (C: 6.5±0.9; CO: 9.1±0.7; P