CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Conferencia: Dietary lipids and placental function in diabetes mellitus
Autor/es:
JAWERBAUM A
Reunión:
Congreso; Centre for Trophoblast Research Annual Conference 2019; 2019
Resumen:
Impairments in glucose and lipid metabolism in maternal diabetes alter placental function and fetal development, resulting in adverse programming effects in the postnatal life. A prooxidant/proinflammatory intrauterine environment increases placental lipoperoxidation, affecting the availability of unsaturated fatty acids, highly needed for fetal development. Unsaturated fatty acids are natural ligands of the nuclear receptors PPARs, transcription factors whose levels are reduced in the placenta from diabetic rats and from diabetic patients. PPARs are key regulators of antioxidant and anti-inflammatory pathways, and their activation through maternal diets enriched in unsaturated fatty acids have shown beneficial effects in the placenta, fetuses and offspring of diabetic rats as well as in the placenta from diabetic patients. Our results highlight the ability of dietary treatments enriched in PPAR activators to target the placenta, with potential benefits for the intrauterine development in diabetic pregnancies.