The maternal treatment with chia oil in diabetic rats (F0) reduces the overactivation of mTOR pathways in the placenta from their offspring (F1) that develops gestational diabetes mellitus.

ROBERTI, SABRINA; FORNES, DAIANA; JAWERBAUM, ALICIA; GOMEZ RIBOT, DALMIRO; CAPOBIANCO, EVANGELINA

Mar del Plata

Congreso; LXIII Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2018

Sociedad Argentina de Investigación Clínica

The offspring (F1) of mild diabetic rats (F0) develops gestational diabetes mellitus (GDM), a rat model with increased fetal growth associated with the overactivation of placental mechanistic target of rapamycin (mTOR) signaling. Maternal diets supplemented with polyunsaturated fatty acids (PUFAs) have beneficial metabolic effects in the placenta from pregestational diabetic rats. AIM: to study the effect of a maternal treatment with chia oil in diabetic rats (F0), on the fetal weight and placental mTOR pathways in their offspring (F1) that develops GDM. METHODS: control and diabetic rats (F0) were fed with a standard diet or a diet supplemented with 6% chia oil (rich in n-3 PUFAs) (CH group) during gestation. The female offspring (F1) was mated with healthy males. Metabolic parameters and the mTOR signaling pathways (by Western blot) were evaluated in the placenta from control and GDM rats on day 21 of pregnancy.RESULTS: The development of GDM (fasting glycemia values over 130 mg/dl) was not prevented by the chia oil diet. Fetal weight was increased in the GDM group (26%, p