Oxytocin inhibits inflammation in lipopolysacharide-treated Sprague Dawley male adult rats.

DMYTRENKO G; DE LAURENTIIS A; FERNANDEZ SOLARI J; SURKIN PN

Mar del Plata

Congreso; LVIII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2018

SAIC

The hypothalamo-neurohypophysial system emerged as a componentof neuroendocrine?immune network, wherein the oxytocin (OXT)-secretingsystem, plays an essential role. Recent data indicatethat OXT regulates the immune response and have anti-inflammatoryproperties. Our previous studies provided evidence for the enhancementof OXT production and release following immune challenge.Also, we found that OXT reduced TNF-alpha release fromglial cells cultured with an endotoxin.In the present work, a systemic lipopolysaccharide (LPS)-treatedacute inflammation rat model was used to study the suppressiveeffects of OXT against neuroinflammation. A peripheral injection ofLPS was administered to evoke neuroinflammation in adult maleSprague Dawley rats. LPS was dissolved in sterile 0.9% salinevehicle. The LPS groups were i.p. injected with LPS (5 mg/kg). Inthe control group, rats were injected i.p. with vehicle. OXT groupswere injected with OXT (10, 100 and 1000 ug/kg, sc) 15 min previousto vehicle or LPS administration. OXT 100 and 1000 ug/kgsignificantly (p