Olive oil supplementation reduces proinflammatory markers in the placenta in a GDM rat model induced by intrauterine programming

CAPOBIANCO, EVANGELINA; JAWERBAUM ALICIA; RIBOT, DALMIRO GOMEZ; FORNES, DAIANA; LEVIEUX, CECILIA

Orlando

Congreso; 78th Scientific Sessions. American Diabetes Association; 2018

American Diabetes Association

Gestational diabetes (GDM) is associated with an increased proinflammatory state in the placenta, which affects fetal development and offspring´s health. We have previously found that pregestational mild diabetes in Wistar rats (F0) programs GDM in the adult female offspring (F1). Our aim was to treat this F1 with a diet enriched in olive oil to address the ability of this treatment to prevent both excessive matrix metalloproteinase 2 (MMP2) and connective tissue growth factor (CTGF) levels and reduced PPARgamma levels in the placenta, associated to the proinflammatory state. Methods: Mild pregestational diabetes was induced by neonatal streptozotocin administration (90mg/kg). Pregestational diabetic female rats and controls (F0) were mated with control males, and their adult female offspring (F1) mated with control males. F1 rats were fed a standard diet or a diet supplemented with 6% olive oil during pregnancy. On day 21 of pregnancy, maternal serum and the placenta were evaluated. Results: The olive oil treatment in the F1 pregnancy did not prevent maternal or fetal hyperglycemia in the pregnant offspring of pregestational diabetic rats. Maternal supplementation with olive oil reduced maternal triglyceridemia in GDM rats (21%, p