CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Impaired decidual PPAR signaling in diabetic rats at early pregnancy
Autor/es:
ROBERTI, SABRINA LORENA; HIGA, ROMINA; SATO, HUGO; JAWERBAUM, ALICIA; HEINECKE, FLORENCIA
Lugar:
Tokio
Reunión:
Congreso; International Federation of Placenta Associations; 2018
Resumen:
Objectives Maternal diabetes impairs embryo and placental development, an alteration that may start at early pregnancy. Histotrophic nutrition is relevant at the early postimplantation stage. Peroxisome proliferator activated receptor gamma (PPARgamma), a ligand activated transcription factor essential in development and a master regulator of lipid metabolic pathways, may be involved in histotrophic nutrition. Our objective was to evaluate PPARgamma and its target genes perilipin 2 (PLIN2) and fatty acid binding protein 4 (FABP4) in the decidua from 9-day-pregnant control and diabetic rats.Methods Diabetes was induced by streptozotocin administration (50 mg/kg) in female Wistar rats two weeks before mating with control males. On day 9 of pregnancy the decidua was explanted and prepared for evaluation of PPARgamma by Western blot and PLIN2 and FABP4 by immunohistochemistry.Results PPARgamma was increased in the decidua from diabetic rats compared to controls (30%, p