Enriched environment as an effective strategy to reverse hippocampal-related behavioral and molecular changes after an early chronic noise exposure

MOLINA SJ; CAPANI F; RODRIGUEZ GONZALEZ M; GUELMAN LR; BUJÁN GE

Córdoba

Congreso; XXXIII Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias; 2018

Sociedad Argentina de Investigación en Neurociencias (SAN)

Noise exposure can induce hippocampal (HC)-related behavioral and molecular alterations that could be prevented by housing rats in enriched environment (EE). As the effects of EE housing during longer periods were not explored, the aim was to test behavioral and HC oxidative markers after exposure to noise at 7 and 15 days (N7 and N15) and the possible reversal after 2 weeks of EE housing.Male N7 and N15 Wistar rats were exposed to noise for 2 h for 5 days. After weaning, rats were transferred to an EE, while others were placed in standard cages (S). After 1 or 2 weeks, different behaviors as well as HC levels of Trx1 and Trx2 were evaluated.Results showed that N7-S1 had an increase in associative memory and anxiety-like behaviors (AB), whereas N7-EE1 showed a full prevention. In contrast, no behavioral changes were observed in N7-S2. On the other hand, N15-S1 showed an increase in exploratory behavior and EE was unable to restore it. N15-S2 presented a decrease in AB that was reversed by EE housing.Finally, whereas N7 and N15-S1 showed an increase in Trx1 levels that were reversed in EE1, no changes were observed after an additional week. On the other hand, HC Trx2 levels were increased in N7-S1 and S2.These findings suggest that rats exposed to noise at different developmental ages might differentially affect behavioral and molecular parameters. Furthermore, EE might be an effective strategy to reverse most alterations that seems not to depend on the housing length.