CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Maternal diets enriched in olive oil prevent lipid accumulation in the fetal liver
Autor/es:
CAPOBIANCO EVANGELINA; ALICIA JAWERBAUM; DAIANA FORNES, VERONICA WHITE,
Lugar:
Tokio
Reunión:
Congreso; International Federation of Placenta Associations (IFPA); 2018
Institución organizadora:
IFPA
Resumen:
In GDM rats, the liver of male fetuses accumulates lipids, an alteration possibly involved in the programming of metabolic diseases in later life. We aim to evaluate whether a maternal diet enriched in olive oil is capable of regulating lipid accumulation in the fetal liver, through the regulation of PPARs and their target genes involved in lipid metabolism. Methods:Mild diabetic rats (F0) were obtained through neonatal streptozotocin administration, mated in the adulthood (F0 pregnancy) and their female offspring mated with control males (F1 pregnancy). In their F1 pregnancy GDM was developed through intrauterine programming. The liver of male fetuses from GDM rats and controls were explanted on day 21 of pregnancy. Results: Triglycerides and cholesterol were increased in the fetal livers from GDM rats (53% and 48%, respectively; p