CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
INVOLVEMENT OF INFLAMMATION AND APOPTOSIS IN THE ADRENOCORTCIAL DYSFUNCTION IN INSULIN RESISTANT RATS: EFFECT OF HEMIN TREATMENT
Autor/es:
CAROLINA VERÓNICA VECINO; SILVIA SANCHEZ PUCH; MORENA WISZNIEWSKI; CORA B. CYMERYNG; CALDARERI LILIAN; ESTEBAN MARTÍN REPETTO
Lugar:
Mar del Plata (Buenos Aires)
Reunión:
Congreso; LXIII Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica; 2018
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
The worldwide increase in the consumption of sweet beverages has been linked to the generation of insulin resistance (IR). In rats with diet-induced IR, oxidative stress and chronic inflammation have been detected in several tissues. As an adrenocortical dysfunction was previously demonstrated in rats fed 30% sucrose in the drinking water (SRD), we analyzed the effect of HO-1 induction, an antioxidant enzyme, on functional parameters in the adrenal cortex. Rats were randomly distributed in Control and SRD-groups and treated for 13 weeks. Some animals from both groups received hemin (15 mg/kg i.p every 48 h; H and SRDH groups) and treatments went on for 2 more weeks. Statistical significance of data was analyzed by ANOVA followed by Tukey?s test.Induction of HO-1 was detected in the adrenal cortex of both hemin treated groups (p