IL33 receptor expression is significantly up-regulated on B cells during pregnancy

VENTIMIGLIA MARÍA SILVIA; ABBA MARTÍN ; VALEFF NATALÍN J; MUZZIO DAMIAN ; ZYGMUNT M; JURIOL LORENA; QUIROGA FLORENCIA; JENSEN FEDERICO

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Inmunología (SAI)

IL33 is an alarmin released during cell injury caused by stress or infection and drives immune cells into regulatory functions to maintain tissue homeostasis.In the context of pregnancy, IL33 was recently shown to induce the production of anti-inflammatory molecules by decidual B cells, protecting against preterm labor in human and mouse.Here we aimed to fully characterize the expression of IL33 receptor (IL33R) in B cells during pregnancy.We began performing a genome-wide transcriptome profiling in pure isolated B cells from the spleen of pregnant (P) and non-pregnant C57BL/6 mice (NP). Interestingly, we observed that expression of Il1rl1 (IL33R) was significantly upregulated (≈ 4,5 fold changes) in B cells from P compared to NP mice using Limma eBayes test (p