CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
EPIGENETIC CONTROL OF EARLY NEURODEGENERATIVE EVENTS IN DIABETIC RETINOPATHY BY THE HISTONE DEACETYLASE SIRT6. INVOLVEMENT OF MÜLLER GLIA.
Autor/es:
MARIA ZORRILLA ZUBILETE; DEBORAH TOIBER; ADA YESTE; MOSTOSLAVSKY R; D.M. SILBERMAN; QUINTANA, FRANCISCO J.
Lugar:
Washington, DC
Reunión:
Congreso; SFN, Neuroscience 2017, , November 11-15; 2017
Institución organizadora:
Society for Neuroscience
Resumen:
Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus (DM) and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease but may be a result of neurodegenerative processes and that glucose-induced neuron and glial cell damage may occur shortly after the onset of diabetes making the disease hard to diagnose at early stages. SIRT6, a NAD-dependent sirtuin deacylase, modulates aging, energy metabolism and neurodegeneration. In previous studies we showed that SIRT6 deficiency causes major retinal neurotransmission defects, changes in expression of glycolytic genes and elevated levels of apoptosis. Given the importance of glucose availability for retinal function and the critical role for SIRT6 in modulating glycolysis, we aim to analyze SIRT6 involvement in early neurodegenerative events during the development of experimental DR. Using non-obese diabetic mice (NOD/ShiLtJ), we determined by Western blot that two weeks after the onset of the disease high glucose concentrations (>250 mg/dl) induced retinal increased of a neovascularization promoting factor (VEGF, p