ADRENOCORTICAL INSUFFICIENCY DUE TO A SUSTAINED INCREASE IN THE AVAILABILITY OF SUCROSE IN THE DIET

MORENA WISZNIEWSKI; CORA BEATRIZ CYMERYNG; JUAN SALVADOR CALANNI ; ESTEBAN MARTÍN REPETTO; CAROLINA VERÓNICA VECINO; SILVIA SANCHEZ PUCH

CABA

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

SAIC, SAI, SAIB, SAFIS, SAFE

Obesity and insulin-resistance (IR) have been linked to an increase consumption of sweet beverages. Higher glucocorticoid levels could worsen this condition. In this study we evaluate long term effects of the administration of a sucrose-rich diet (SRD) on the morphology and function of the adrenal gland and assessed the therapeutic effect of hemin treatment. Rats were randomized into 4 groups (n=4): Control, SRD-fed rats (C, SRD) and C and SRD-fed rats receiving 15 mg/kg hemin (ip) (H and SRD+H) during the last two weeks of the experimental period (12 weeks). Statistical significance was analyzed by ANOVA followed by Tukey´s post hoc test. At the end of the experiment, serum metabolites such as glucose and total cholesterol levels (vs. C, p