CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ENDOMETRIAL STATUS OF PATIENTS WITH POLYCYSTIC OVARY SYNDROME WHOSE DID NOT RESPOND TO METFORMIN TREATMENT
Autor/es:
EVELIN MARIEL ELIA; EDUARDO LOMBARDI; CAROLINA PUSTOVRH; LUIGI DEVOTO; ALICIA BEATRIZ MOTTA
Lugar:
San Salvador de Bahia, Brasil
Reunión:
Congreso; Simposio Mundial de Ginecologia Endócrina y V Congreso Brasilero de Ginecologia Endócrina; 2009
Institución organizadora:
Asociación Brasilera de Ginecología Endócrina (SOBRAGE) y Asociación Internacional de Ginecología Endócrina (ISGE)
Resumen:
The 82 % of women diagnosed with Polycystic Ovary Syndrome (PCOS) suffer recurrent abortions. The objective of this work was to assess the state of the endometrial tissue of PCOS patients who had not responded to Metformin treatment since they failed to become pregnant. Samples of blood and endometrium were collected after women signed a written consent. The control group (n = 18) consisted in women underwent laparoscopy for diagnosis of non-ovarian pathology, PCOS group: women with PCOS (n = 20) without treatment, PCOS+Metformin: women whose did not respond to Metformin (1500 mg/ day) treatment (n = 20). Women from the PCOS group showed increased levels of LH while Metformin reversed this effect (control: 4.1+2.8; PCOS: 13.7+3.1; PCOS+Metformin: 6.9+2.2 mIU/ml). Neither FSH, prolactin, androstenedione nor glycemia were altered in PCOS group. The type of glandular structures of PCOS epithelium was pseudostratified and according to a proliferative status. In contrast, the endometrium from the PCOS+Metformin group acquired changes forming secreting glands. The endometrium from PCOS+Metformin group showed lower apoptotic cells (assessed by TUNEL) than that from PCOS but higher than control. Conclusions: The endometrial tissue of women with PCOS show glands with proliferative structures and enhanced apoptotic cells, unfavorable conditions for implantation. Metformin reverses the type of glands toward the secretory stage and reduces the number of apoptotic cells but these changes are not enough to ensure the implantation of the embryo. The data from PCOS+Metformin group correlates with a forth group of women with recurrent aborts (n= 10) also analyzed.