EXPOSURE OF ADOLESCENT RATS TO NOISE AND ALCOHOL INDUCED HIPPOCAMPAL-RELATED BEHAVIORAL ALTERATIONS AND MODIFICATIONS IN THE ENDOGENOUS ANTIOXIDANT TRX-1

GUELMAN, L.R

Buenos Aires

Simposio; 1st International Symposium of the Developmental Origins of health and disease (DOHAD), Ibero-American Chapter; 2017

International Society of Developmental Origins of Health and Disease (DOHAD)

Exposure to physical (e.g., noise) or chemical (e.g., alcohol) agents can induce diverse behavioral and/or biochemical alterations, especially in young people. Therefore, considering the likelihood to undergo a combined exposure to both agents, the aim of the present work was to investigate in an animal model whether noise exposure during adolescence could be capable of generating hippocampal-related behavioral and/or oxidative alterations and if these changes might be modified by alcohol intake.Male Wistar rats (28-days-old) were exposed to noise (95-97 dB, 2h). Subsequently, animals were allowed to voluntarily drink alcohol (10 % ethanol in tap water) for three days. Afterwards, hippocampal-related memory and anxiety assessment tests were performed. Finally, hippocampal Trx-1 levels were determined.Results show that whereas noise-exposed rats presented deficits in habituation memory, those who consumed alcohol evidenced a deficit in associative memory and anxiety-like behaviors. In contrast, combined exposure produced increases in exploratory activity and anxiety-like behaviors, being different to what was observed using each agent separately. In addition, increased hippocampal Trx-1 levels were found in these animals.These results suggest that exposure to physical and chemical stressors during adolescence could induce behavioral alterations that differ depending on the schedule and the agent used and can be accompanied by oxidative state changes. In fact, different alterations were observed when both agents were presented sequentially, confirming a high vulnerability of the developing brain to these potentially clinically relevant agents.