Fetal Growth and Development Symposia. Título de charla: ?What drives excessive fetal adiposity?

JAWERBAUM A.

Congreso; AUDIT meeting, 48th Meeting, Diabetes and Pregnancy Study Group (DPSG), EASD.; 2016

Outline for DPSG Audit - Session C1Alicia Jawerbaum / Sylvie Hauguel de Mouzon/ Louise Kelstrup/ Emilio Herrera/What drives excessive fetal adiposity? Background 1-Impaired maternal homeostasis?Excessive metabolites glucose?Excessive metabolites: lipids?Excessive Insulin Resistance2-Impaired placental homeostasis?Maternal-Fetal transfer function?Endocrine function Points to discuss?Fetal lipid metabolic activity ?Role of PUFAs: quantity and quality?Link between adiposity: Insulin, cytokines and PPARs pathways?Link between adiposity: Immune-inflammatory pathways?Link between adiposity and adverse intrauterine programming Areas and questions for further research1-Define the goals to achieve and the targets to impact : ?Should we adapt maternal diet or energy expenditure? ?Should we target fetal leptinemia and /or insulinemia? ?Should we prevent excess inflammation? 2- Do we have the right tools to do so? ?Maternal strategies (diet/lifestyle)?Placental strategies: miRNAS/cfDNA/others 3- Define the Timing of intervention