CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Melatonin Treatment Prevents Pituitary Dysfunction Induced By a Sucrose Rich Diet.
Autor/es:
CALANNI JS; VECINO, CV; PEREZ, MATÍAS; SANCHEZ PUCH, S; MERCAU, MARÍA E.; CYMERYNG, CORA B.; ARANDA, M; REPETTO, EM
Lugar:
Boston, MA
Reunión:
Congreso; The Endocrine Society's 98th Annual Meeting and Expo; 2016
Institución organizadora:
Endocrine Society
Resumen:
Excessive consumption of foods and beverages with high sugar content has been associated an increased incidence of insulin resistance (IR) and obesity worldwide. Several reports have shown a concomitant dysfunction of the hypothalamus-pituitary-adrenal (HPA) axis in these patients. We have previously reported that rats fed a sucrose-rich diet (SRD, 30% sucrose in the drinking water) show higher fasting blood levels of glucose, triglycerides and non-esterified fatty acids (NEFA) that were accompanied by higher circulating corticosterone levels and a significant decrease in insulin sensitivity. The aim of this study was to evaluate the activity of the HPA axis in rats treated with SRD for 3 weeks, when changes in insulin sensitivity were still not evident and to determine the underlying mechanisms. Our results showed augmented levels of circulating ACTH and corticosterone in SRD- treated rats (200% and 56% respectively, p