Disorders in the sexual maturation, ovulation and oocyte quality in female offspring caused by maternal overweight

CORTEZ, ANALÍA ELIZABETH; RHON CALDERÓN, ERIC ALEJANDRO; GALARZA, ROCÍO ALEJANDRA; FALETTI, ALICIA GRACIELA

Beijing

Congreso; 17th International Congress of Endocrinology from International Society of Endocrinology; 2016

International Society of Endocrinology

Overweight and obesity constitute a health problem of increasing prevalence and present a majorpublic health concern that affects men and women, young and old and results in numerous healthdetriments, including disruptions in reproductionOBJECTIVE: The aim of this work was to study the effect of the maternal overweight/obesity on the ovarian reserve, follicular development and ovulation, and to assess whether this maternal condition alters the oocyte quality.METHODS: Resulting female offspring from rats fed with standard (OSD) or cafeteria (OCD) diet were used. Body weight, vaginal opening and estrous cycle were recorded and ovaries were obtained on the day of second estrus. In addition, ovarian weight, ovulation rate (measured by the number of oocytes within oviducts), follicular development (determined by histology), and oocyte morphology and viability were examined. OCD rats were divided in two groups, offspring from rats with 17% (OCD17) and rats with 28% of overweight (OCD28).RESULTS: Compared with OSD both groups of OCD showed higher body weight (OCD17 24%, P