CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
HIPPOCAMPAL-RELATED BEHAVIORAL ALTERATIONS INDUCED BY PRENATAL STRESS COULDBE PARTIALLY REVERTED BY ENRICHED ENVIRONMENT.
Autor/es:
RAMBORGER M; ZORRILLA ZUBILETE, M.A.; GENARO, A.M.; LARRECHE CALARROHANO R
Lugar:
Mar del Plata
Reunión:
Congreso; LXI Reunión Científica de la Sociedad Argentina de Investigación Clínica (SAIC),; 2016
Institución organizadora:
SAIC, SAFE, SAI
Resumen:
During neurodevelopment, mice have an increased susceptibilityto the deleterious effects of prenatal time insults, hich havean impact on memory, learning and anxietyrelated behaviors.Some of these changes are associated ith an alteration of theHA axis response. e aim to evaluate the effect of enrichedenvironment (EE) on hippocampal-related behavioral impairmentinduced by prenatal restraint stress.regnant female alb/cmice ere individually restrained hours/day, since the thday of gestation until delivery. ffspring ere initially divided intodifferent groups prenatal stress S, no prenatal stress C, inturn each group as treated ith EE. The offspring ere testing days after birth.alb/c subjected to S shoed impairment inhabituation memory to an pen Field Test, and this as revertedmeaningfully by the EE p.. n addition, an increase in anxietybehaviors as observed in S mice p., hich as revertedby EE in the elevated plus maze test. n an bject in place test,S performance in the discrimination tas as altered hencompared to control mice p., and EE could not revert thisdisability. oreover, a significant increase p.in glucocorticoidreceptors as found in both the hippocampus and lymphoidcells of S mice, but as reverted by EE, up to control levels.Corticosterone plasma levels ere increased in acute stress miceand in Sacute stress mice, the first shoing higher levels. EEhas proven successful in reversing this effect in the S group. nconclusion, these results support the idea that PS induces changesin the HA axis, ith a subsequent altered response to stressexposure in the adult life. The behavioral alteration provoed byS could be related to higher levels of in the hippocampusand lymphatic ganglia. These changes ere partially revertedby EE. Finally, it is important to note that lymphocytes could beperipheral marers of HA alteration induced by S. Funding and ACyT