BEHAVIORAL AND MOLECULAR CHANGES INDUCED BY EARLY NOISE EXPOSURE USING DIFFERENT EXPOSURE SCHEDULES. PARTIAL REVERSAL AFTER REARING IN AN ENRICHED ENVIRONMENT

MICELI, M; MOLINA, SJ; GUELMAN, LR; CAPANI, F

Buenos Aires

Congreso; Federation of Latin American and Caribbean Neuroscience Societies (FALAN) Congress and XXXI Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN); 2016

Sociedad Argentina de Investigación en Neurociencias

Different schedules of noise exposure can induce dissimilar behavioral hippocampal-related changes in immature rats. Moreover, rearing animals in an enriched environment (EE) has shown to be effective in the reversal of most alterations. However, comparative data of hippocampal oxidative status were not obtained yet.Thus, the aim of this work was to test potential schedule-related differences in the levels of the hippocampal endogenous antioxidant Trx1 as well as related behavioral parameters. The possible reversal of these changes by rearing in an EE was also assessed.Male Wistar rats of 7 days were exposed to noise (95-97 dB, 2h daily, for one or five days). After weaning, rats were transferred to an EE or to standard cages. After one week, behavioral tests were performed and levels of Trx1 were evaluated.Results showed that noise exposure might induce different hippocampal-related behavioral and Trx1 changes, depending on the schedule of exposure. Moreover, rearing in an EE was effective in modifying some of these endpoints. However, although 5-days exposed rats appeared to be more vulnerable to noise-induced changes than 1-day exposed animals, EE was equally effective in reversing changes in both groups.Therefore, it could be concluded that although the repeated exposure to noise might be more damaging on behavioral and oxidative measures, enriched stimulation during the development seemed to be an effective strategy to reverse all noise-induced changes.