CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
1. Muscarinic modulation of paclitaxel actions on human breast cancer
Autor/es:
DI BARI M; TATA AM; ESPAÑOL A; CRISTOFARO I; SALEM A; SALES ME
Lugar:
Phoenix
Reunión:
Congreso; 2nd World Congress on Breast Cancer; 2016
Institución organizadora:
Conference Series LLC
Resumen:
Cholinergic modulation of tumor progression has been described in different experimental models. In our laboratory, we demonstrated that long term treatment of murine mammary tumors with the non-selective agonist, carbachol (CARB) promotes cell death through the activation of muscarinic (M) receptors. We studied the effect of a combination of sub threshold doses of CARB (10-12M) with paclitaxel (PX) (10-8M) a cytotoxic agent used in the treatment of breast cancer, on MDA-MB231 cells derived from a human triple negative breast tumor. The combination of CARB+PX reduced cell viability by 27±3% (p