Maternal obesity induces latent metabolic alterations in offspring when subjected to a high fat diet.

ANA PAULA DOMINGUEZ RUBIO; AISEMBERG JULIETA; BARIANI MARIA VICTORIA; ANA MARIA FRANCHI

Buenos Aires

Congreso; Scientific meeting of the International Association of the Diabetics and Pregnancy Study Groups.; 2016

The prevalence of maternal obesity has risen dramatically and could significantly impact the fetal development. Children from obese mothers have an increased risk of developing obesity as well as several diseases, including cardiovascular disease and hypertension. The endocannabinoid system (ECS) participates in the control of energy balance and regulates lipid metabolism and the accumulation of energy as fat. Therefore, a disregulation in the ECS might contribute to excessive visceral fat accumulation and to the onset of several metabolic risk factors associated with obesity.We had developed a high fat diet (HFD: standard food + 30% fat)-induced maternal obesity model in CD1 wild type (WT) and cannabinoid receptor type 1-knockout (CB1-KO) mice. The aim of this study was to evaluate the weight gain as well as several markers of obesity in offspring (both WT and CB1-KO) from HFD-treated and control mothers, when subjected to a HFD or standard diet.We observed that pups (both WT and CB1-KO) born to obese mothers had higher weight at birth and during lactation period (p