CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
INFLUENCE OF CHRONIC MILD STRESS ON THE EVOLUTION AND IMMUNE RESPONSE OF STREPTOZOTOCIN INDUCED TYPE I DIABETES
Autor/es:
RUBINSTEIN R.; WALD M.R.; GENARO A.M.
Lugar:
Tandil, Buenos Aires
Reunión:
Congreso; XL Reunión Anual de la Asociación de Farmacología Experimental; 2008
Institución organizadora:
Asociación Argentina de Farmacología Experimental
Resumen:
Experimental literature suggests a relation between diabetes and immunosuppression. However, there are diabetic patients with normal evolution after an infection challenge. Between the factors that can regulate this susceptibility are the stressful life events. Here, we studied the effect of chronic mild stress exposition (CMS) on the development and evolution of STZ type I induced diabetes in Balb/c mice and its correlation with the immune response. Results indicate that CMS exposition after diabetes induction lead to significantly higher levels of glucose than those observed in non exposed animals. Concerning the immune response, in animals with CMS exposition after diabetes induction, T and B lymphocyte proliferative response to selective mitogens was lower than animals exposed to diabetes or CMS alone. Participation of hyperactivation of hypothalamo- pituitary-adrenal (HPA) axis was estimated by determination of serum level of corticosterone, a hyperglycemic hormone. No correlation was observed between increased corticosterone levels, glycemia and decrease of immune response. However a positive correlation was observed between hyperglycemia and inhibition of immune response. These findings indicate a detrimental association of stress with the prognosis of diabetes through a glycemic increase and a reduction of immune response.