Corpus callosum index to measure brain volume loss in clinical practice in MS patients

ROJAS JUAN IGNACIO; SANCHEZ FRANCISCO; PATRUCCO LILIANA; MIGUEZ, J.; CRISTIANO EDGARDO

Barcelona

Congreso; 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis; 2015

European Committee for Treatment and Research in Multiple Sclerosis

Sophisticated MRI techniques, often inaccesible in clinical practice,are requiered to analyze brain volumen loss in multiple sclerosis(MS) patients. The corpus callosum index (CCI) is anormalized measurement that reflects changes of brain volumenand was proposed as an easy and practical tool to measure brainvolume changes, however, it´s reliability was not entirely demonstratedwith standard brain volumen loss techniques currentlyused. The objective of the study was to correlate CCI measurementsat baseline and during the follow up with SIENAX andSIENA software in MS patients.Methods: A 2 year prospective study, enrolling consecutiverelapsing-remitting MS (RRMS) patients with less than 3 years ofdiseaese onset was performed. On a conventional best mid-saggitalT13D sequence, CCI was obtained by measuring anterior, mediumand posterior segments of CC, and normalized to its largest anteroposteriordiameter. SIENA and SIENAX software was used asgold standard and to perform correlation. MRI was performed inall patients at baseline and every year during 2 years.Results: We included 54 RRMS patients, mean age 34 +-5 years,65% women, mean EDSS 1.5 +- 0.5 and all under DMD treatment.CCI at diagnosis was 0.38 +/- 0.04 and correlated with totalbrain volumen at baseline (r 0.71 p< 0.001), at year 1 and 2 (r 0.68p< 0.001 and r 0.73 p < 0.001 respectively). CCI anual decreasewas 0.01 +- 0.01 and 0.02 +- 0.01 for year 1 and 2 respectivelyand strongly correlated with SIENA (r 0.68 p< 0.001and 0.73 p<0.001 for year 1 and 2 respectively).Conclusion: CCI demonstrated a strongly correlation with morecomplex techniques used to measure brain volumen loss