CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Early structural changes in relapsing remitting multiple sclerosis patients with depression
Autor/es:
ROJAS JUAN IGNACIO; PATRUCCO LILIANA; SANCHEZ FRANCISCO; MIGUEZ, J.; CRISTIANO EDGARDO
Lugar:
Barcelona
Reunión:
Congreso; 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis; 2015
Institución organizadora:
European Committee for Treatment and Research in Multiple Sclerosis
Resumen:
Some studies suggest an inflammatory mechanism associatedwith depression in MS. We investigated the association of structuraldamage and depression in MS patients.Methods: A prospective study including patients with RRMS, withless than three years of disease onset, EDSS ⩽3 and no history ofdepression were included. Patients were classified in depressed(D-MS) and non-depressed (nD-MS) based on the clinical assessmentfor depression and Beck Depression Index Scale at inclusion.Brain dual-echo, high-resolution T1-3D weighted and DT MRIscans were acquired from MS patients and healthy controls (HC).Between-group differences of GM and WM volumes were assessedusing SIENAX and FIRST software (p< 0.05). Tract-based spatialstatistics was used to define the regional distribution of DT MRIabnormalities in WM (FMRIB?s Diffusion Toolbox).Results: 65 individuals, 20 HC, 22 nD-MS and 23 D-MS patientswere included. No differences in demographics and clinical variableswere observed. In D-MS patients a decrease in total brain volume (p< 0.01), gray matter volume (< 0.01) and an increase in T2 lesion load(p < 0.01) were observed compared with nD-MS. No differences inwhite matter volume as well as in overall fractional anisotropy (FA)and axial diffusivity values between groups were observed.Conclusion: Patients with D-MS had a more diffuse and focalstructural damage than nD-MS. Measures derived from differentMR modalities, is a promising approach to improve the understandingof the pathophysiology of depression in MS.