CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The exposure to enriched environment prevents retinal ischemic damage
Autor/es:
GONZALEZ FLEITAS M FLORENCIA; DORFMAN D; ROSENSTEIN RE
Lugar:
Mar del Plata
Reunión:
Congreso; XXX- SAN- Annual Meeting; 2015
Institución organizadora:
Sociedad Argentina d eInvetigación en Neurociencias
Resumen:
Sensory SystemsP232.-The exposure to enriched environment prevents retinal ischemicdamageMaría Florencia González Fleitas, Damián Dorfman, Ruth E. RosensteinLaboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Departamento de BioquímicaHumana, Facultad de Medicina, Universidad de Buenos Aires, CEFyBO, CONICET, Buenos Aires,Argentinaflorgf_88@hotmail.com_____________________________________________________________Ischemia is a key component of several retinal diseases that are leading causes ofirreversible blindness. At present, there are no effective strategies to prevent retinalischemic damage. We have demonstrated that the exposure to an enriched environment(EE) after retinal ischemia reduces functional and histological alterations induced byischemia. EE constitutes a strategy that boosts exploratory, visual, and cognitive activities,social interaction and voluntary physical exercise. In this context, the aim of the presentwork was to analyze the effect of EE housing before acute retinal ischemia damage. Forthis purpose, adult male Wistar rats were exposed to standard environment (SE) or EE for 3weeks before retinal ischemia. EE consisted of big cages housing 6 animals and containingseveral food hoppers, wheels and different objects repositioned once/day and fullysubstituted once/week. Ischemia was induced by increasing intraocular pressure to 120mm Hg for 40 min. After ischemia, both groups were housed in SE for 3 weeks, andsubjected to electroretinography (electroretinogram, ERG) and histological analysis. Inanimals previously housed in SE, ischemia induced a significant decrease in ERG a- and bwaveamplitude, and retinal ganglion cell (RCG) loss, whereas the exposure to EEsignificantly prevented these alterations. These results suggest that the EE housing, a noninvasivestrategy, could reduce retinal vulnerability to ischemic damage.