CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effect of antidepressant treatment on tumor growth in a chronic restrain model
Autor/es:
FRICK L; KLECHA A; PALUMBO ML; CREMASCHI G; GENARO AM
Lugar:
Madrid, España
Reunión:
Congreso; 2nd Iberoamericam Congress on Neuroimmunomodulation; 2007
Institución organizadora:
International Society for Neuroimmunomodulation
Resumen:
Chronic stress is involved in the onset of specific psychiatric diseases such as major depression. Stress also affects the immune response. T-cell mediated immunity is a key component in solid tumor rejection. Depression of antitumoral immunity induced by stress could contribute to tumor growth, and antidepressant treatment could prevent this effect. We studied the effects of chronic stress and antidepressant treatment in the immune response as well as in the evolution of neoplasic pathology. BALB/c mice were subjected to chronic restraint stress (CRS), a well validated model of depression. Lymphocyte proliferation to a T selective mitogen was evaluated by [3H]-thymidine incorporation. A significant reduction in T cell proliferation was observed in CRS animals. CRS and normal syngeneic mice were subcutaneously injected with 1x106 LBC T lymphoma cells to generate a solid tumor. Measures of tumor volume indicated that growth is increased in CRS mice. To test if these effects are reversed by antidepressant treatment, CRS mice were concomitantly treated with 15 mg/kg fluoxetine. Fluoxetine prevented T cell impaired proliferation in CRS animals. Moreover, these animals showed the same lymphoma evolution than their normal counterparts. These results suggest that stress-related depressive state promotes tumor growth by depressing T-cell mediated immunity and that chronic antidepressant treatment prevents enhanced tumor evolution by reversing T-cell impairment.