Uterine function in Polycystic Ovary Syndrome

SILVANA FERREIRA; ALICIA BEATRIZ MOTTA

Chascomus

Congreso; XVI Jornadas Anuales de la SAB; 2014

UTERINE FUNCTION IN POLYCYSTIC OVARY SYNDROME Ferreira SR, Motta AB. CEFyBO UBA CONICET (silvanarocioferreira@gmail.com) Polycystic Ovary Syndrome (PCOS) is a common endocrine system disorder among women of reproductive age. The aim of this study is to evaluate how uterine function is affected by polycystic ovary syndrome (PCOS) development. By using a PCOS murine model, pregnant Sprague Dawley rats were separated in: control (C) and prenatal hyperandrogenized (HA) rats. We evaluated inflammatory and oxidant status and the profile of peroxisome proliferator-activated receptor (PPAR) gamma of uterine tissue from the offspring from C and HA. We study the fertility at the adult stage with and without hormonal induction. Increased levels of Prostaglandin E (PGE) and the protein expression of the limiting enzyme of PGs, COX-2 were observed. These results suggest the existence of a pro-inflammatory uterine environment. No differences were obtained between the antioxidant, glutathione levels and lipid peroxidation index, suggesting an oxidant/antioxidant equilibrium. Increased levels of PPAR were found in HA. The fertility rate decreased in HA. The hormonal induction reversed the fertility rate similar found in the C group. We conclude that hyperandrogenism affects the uterine function in a murine PCOS model thus altering fertility rate.