CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Dietary treatment with olive oil regulates PGC-1 expression and matrix metalloproteinases activity in embryo and decidua from diabetic rats
Autor/es:
HIGA R; MAZZUCCO MB; KURTZ M; MARTINEZ N; JAWERBAUM A
Lugar:
Foz do Iguazú
Reunión:
Congreso; V SLIMP Latin American Symposium on Maternal Fetal Interaction and Placenta; 2013
Resumen:
Background: Our previous studies have shown increased MMPs and impaired PPAR signaling in diabetic embryopathy. PPAR signaling is activated by its coactivator PGC-1 and by its ligands oleic acid and certain eicosanoids derived from arachidonic acid through the activity of desaturases.    Aims/Methods: To analyze the effect of a 6% olive oil-supplemented diet (OL) (enriched in oleic acid) to control and diabetic rats from days 1 to 10.5 of pregnancy on decidual PGC-1 and desaturase expression (PCR) and embryonic and decidual MMPs activity (zymography).    Results: We found reduced decidual PGC-1 and delta5 and delta6 desaturase expression in the diabetic group and that OL treatment increased PGC-1 expression. MMPs overactivity in embryos and decidua from diabetic rats was prevented by OL treatments.    Conclusion: Maternal diabetes alters regulators of PPAR signaling in the decidua, and OL treatment improves both PPARs signaling and prevents MMPs overactivities in embryos and decidua from diabetic rats.