Alterations in PPARs and pro-inflammatory markers in the placenta from type 2 diabetic patients.

FORNES D, CAPOBIANCO E, HIGA R, JAWERBAUM A.; DI MARCO I, BASUALDO MN; FAINGOLD MC

Foz do Iguaçu

Congreso; V SLIMP ? Latin American Symposium on Maternal Fetal Interaction and Placenta.; 2013

PPARs are nuclear receptors involved in pro-inflammatory pathways. Aim: To identify PPARs and pro-inflammatory alterations related to the remodeling of the extracellular matrix and the infiltration of immune system cells in the placenta from type 2 diabetic patients. Methods: The protein expression of PPARs (Western blot), the lipoperoxidation (TBARS) and the levels of the connective tissue growth factor (CTGF), collagen and markers of the infiltration of neutrophils (myeloperoxidase) by immunohistochemistry were evaluated in term placentas from healthy (control) and type 2 diabetic patients. Results: In placentas from diabetic patients, there were no changes in the protein expression of PPARdelta and reductions in PPARalpha and PPARgamma when compared to controls (p lower than 0.05). Lipoperoxidation, collagen, CTGF and myeloperoxidase were increased when compared to controls (p lower than 0.05). Conclusions: Type 2 diabetes mellitus leads to a pro-inflammatory state in the placenta, possibly related to the impaired PPAR signaling pathways.