INFLUENCE OF ENRICHED ENVIRONMENT IN THE DELETEROUS EFFECT OF PRENATAL STRESS ON BEHAVIOUR. INVOLVEMENT OF NEUROTROPHINS.

J.E. PIVOZ-AVEDIKIAN; M.R. LARRECHE-CALAHORRANO; C.G. PASCUAN; M.A. ZORRILLA-ZUBILETE; A.M.GENARO.

Huerta grande, Cordoba

Congreso; XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2012

Sociedad Argentina de Investigación en Neurociencias

It was described that Prenatal Stress (PS) can influence the behavior of the offspring. The aim of this work was investigate alterations in behavior and neurotrophins expression and the influence of enriched environment in adults animals subjected to PS. For this purpose, pregnant BALB/c mice were individually restrained 2 hour a day, since gestational day 14 until delivery. A group of stressed offspring mice were exposed to enriched environment after weaning. Animals were tested at 2-months of age. Results shown that PS induces an alteration in the performance in the open field and Barnes maze task. A decrease in BDNF levels by Real-Time PCR and western blot was observed in hippocampus and lymphocytes. Moreover, these animals showed an increase vulnerability to adult chronic stress exposure respect to normal animals. Enriched environment improve the performance in behavioral test in both PS non-exposed and exposed to chronic stress animals. These results indicate that the exposure of enriched environment counteracts deleterious effect induced by PS. In addition, it is possible postulate that the lymphoid cell could be a peripheral marker of the alterations that occur in the hippocampus. UBACYT 2002010010633.