Enrichment environment revert deleteriuod effects of prenatal restraint stress on glucocorticoids receptor of prenatal in hippocampus and llymphoid cells of adult mice.

M.R. LARRECHE-CALAHORRANO; J.E. PIVOZ-AVEDIKIAN; C.G. PASCUAN; AM GENARO; M.A. ZORRILLA-ZUBILETE

Huerta grande, Cordoba

Congreso; XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2012

Sociedad Argentina de Investigación en Neurociencias

Stress during pregnancy can impair behavioral responses in the adult offspring and some of these effects are associated with alteration in the HPA axis response. Also, we shown that during neurodevelopment, C57Bl/6 female mice have increased vulnerability to the deleterious effects of stress on learning and memory. Herein, we are presenting a role of enrichment environment on prenatal and adult restraint stress. For this purpose, pregnant mice were restrained 2 hours daily, since gestational day 14 until delivery. The prenatally restraint stressed offspring (PRS) were expose at 2 months of to acute (2h) or chronic (three-week) restrain stress. We found that female PRS showed poor memory performance as compared to matched control in the habituation to an open field test. Moreover there was an increase in corticosterone plasma levels and in glucocorticoid receptors in hippocampus and lymphoid cells from PRS female mice. In addition an altered HPA response after acute and chronic stress exposure was observed in PRS mice. Enrichment environment reverses the alteration observed in PRS mice. We conclude that PRS induce an alteration of HPA axis with an altered response to acute and chronic stress exposure in the adult life. The HPA response is restored by enrichment environment. UBACYT 2002010010633.