Co-administration of plasmids encoding FMDV P12A3C, CD40L or IL-15 enhanced protective immune response against viral challenge.

PEREYRA, E.; GNAZZO, V; SORIA, I; LANGELLOTTI, C.; BELLUSCI, C; D"ANTUONO, ALEJANDRA; MATTION, NORA; QUATTROCCHI, VALERIA; ZAMORANO, PATRICIA; MONGINI, CLAUDIA

Jerez de la Frontera

Simposio; Session of the Standing Technical Committee of the European Commission for the Control of FMD. EuFMD Open Session 2012; 2012

European Commission for the Control of FMD

DNA vaccines offer an economical and safer alternative to traditional vaccines employing inactivated virus. Nevertheless one major drawback is the low potency that constrains to employ adjuvant to enhance DNA vaccine potency. In this study we have evaluated the capacity of inducing a specific and protective immune response using a formulation that includes eukaryotic plasmids encoding the polyprotein pP12A3C form of FMDV O1Campos in combination or not with the molecular adjuvants pCD40L and pIL15 and to evaluate the immune efficacy of these DNA vaccinations in a murine model.