CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
INFLUENCE OF ENRICHED ENVIRONMENT IN THE DELETEROUS EFFECT OF PRENATAL STRESS ON BEHAVIOUR. INVOLVEMENT OF NEUROTROPHINS
Autor/es:
JOANA E PIVOZ-AVEDIKIAN; MARÍA ROCÍO CALAORRO-LARRECHE; CECILA GABRIELA PASCUAN; MARÍA A ZORRILLA ZUBILETE; ANA MARÍA GENARO
Lugar:
Huerta Grande- Córdoba
Reunión:
Congreso; XXVII Congreso Anual SAN; 2012
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
It was described that Prenatal Stress (PS) can influence the behavior of
the offspring. The aim of this work was investigate alterations in behavior and
neurotrophins expression and the influence of enriched environment in adults
animals subjected to PS. For this purpose, pregnant BALB/c mice were
individually restrained 2 hour a day, since gestational day 14 until delivery.
A group of stressed offspring mice were exposed to enriched environment after
weaning. Animals were tested at 2-months of age. Results shown that PS induces an
alteration in the performance in the open field and Barnes maze task. A decrease
in BDNF levels by Real-Time PCR and western blot was observed in hippocampus
and lymphocytes. Moreover, these animals showed an increase vulnerability to adult
chronic stress exposure respect to normal animals. Enriched environment improve
the performance in behavioral test in both PS non-exposed and exposed to
chronic stress animals. These results
indicate that the exposure of enriched environment counteracts deleterious
effect induced by PS. In addition, it is possible postulate that the lymphoid
cell could be a peripheral marker of the alterations that occur in the
hippocampus. UBACYT 2002010010633.