Differential temporal effects of systemic lipopolysaccharide on the inducible regulators of anti-oxidant defense, Nrf2 and PGC-1a, in neonatal rat brain

CORREA F, LJUNGGREN E, WANG X, HAGBERG H, MALLARD C, SANDBERG M.

Londres

Congreso; Hershey Conference on Developmental Brain Injury; 2012

We have earlier showed that systemic lipopolysaccharide (LPS) protects against hypoxia-ischemia (HI) induced injury when given to 8 days rats 24 h before the HI whereas it sensitize the brain to HI 72 h after LPS (Wang et al., 2007). The sensitization was blocked by administration of N-acetylcysteine (NAC) showing that oxidative stress was involved. Here we investigated to major transcriptional regulators of the anti-oxidant defense system, Nrf2 and PGC-1alpha