CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Lipid metabolism in experimental models of diabetes and pregnancy
Autor/es:
JAWERBAUM A
Lugar:
Botucatu
Reunión:
Encuentro; 2do Encuentro translacional de Investigación en enfermedades gestacionales; 2012
Institución organizadora:
. Universidad Estatal Paulista, Campus de Botucatu. Facultad de Medicina
Resumen:
Lipid metabolism is highly impaired in diabetic pregnancies. In fetuses from diabetic rats, lipid metabolism, lipid peroxidation and several pro-inflammatory markers are regulated by the activation of the three PPAR isotypes. Deficiency in polyunsaturated fatty acids (PUFAs) and impaired formation of arachidonic acid derivatives that activate PPARs are observed in diabetic intrauterine tissues. There is an efficient transfer of lipids through the placenta, and maternal treatments enriched in unsaturated fatty acids are capable of activating PPARs in embryos, fetuses and placentas. Our results show that the intrauterine activation of PPARs leads to the regulation of impairments in lipid homeostasis, pro-inflammatory pathways and growth in placentas and fetuses from experimental models of diabetes in pregnancy.