CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Chronic stress influence in the evolution of type I streptozotozin (STZ)- induced diabetes
Autor/es:
ROSSANA RUBISTEIN; ANA MARÍA GENARO; MIRIAM R WALD
Lugar:
Córdoba
Reunión:
Congreso; XXXVIII Reunión Anual de la SAFE; 2006
Institución organizadora:
Asociación de Farmacología Experimental
Resumen:
Environmental factors appear to be nongenetic risks in the progresión of type I diabetes. In particular, stressful life events have been seen linked to the onset of diabetes in humans. However the mechanisms involved are not yet well understood. Here, we studied the effect of chronic mild stress exposition (CMS) on the development and evolution of STZ type I induced diabetes in Balb/c mice. This experimental model of diabetes arrives to mild hyperglycemia allowing a good survival. The results indicate that CMS exposition by six weeks previous STZ administration result in a significant delay in the onset of hyperglycemia compared to matched diabetic controls. On contrary, CMS exposition after diabetic induction conduce to a late significantly higher levels of glucose than those observed in non exposed animals. Glucose levels were correlated with glycosilated hemoglobin. Hyperactivation of hypothalamo- pituitary-adrenal (HPA) axis stimated by determination of serum level of corticosterone, a hyperglycemic hormone, was observed in diabetic animals. Corticosterone levels showed an early significant variation according the time when chronic stress was applied. This levels were lower when animals were exposed previously and higher when was animals were exposed after diabetes induction. This findings indicate that stress influence the onset and evolution of diabetic disease having an important participation the HPA axis.